“Abstract: Necrotizing Fasciitis (NF) is a rare and rapidly progressing bacterial infection of soft tissues. Bacterial toxins cause local tissue damage and necrosis, as well as blunt immune system responses. A self-propagating cycle of bacterial invasion, toxin release and tissue destruction can continue until substantial amounts of tissue become necrotic. Neutralization of bacterial toxins should improve the results.”
Dr. John Crew, MD, Kerry Thibodeaux, MD, FACS, Marcus Speyrer, RN, CWS, Anibal R. Gauto, MD, Timothy Shiau, PhD, Liliana Pang, Keith Bley, PhD, and Dmitri Debabov, PhD
“Abstract: Chronic wounds and the infections associated with them are responsible for a considerable escalation in morbidity and the cost of health care. Infection and cellular activation and the relation between cells are 2 critical factors in wound healing. Since chronic wounds offer ideal conditions for infection and biofilm production, good wound care strategies are critical for wound healing. Objective: The aim of this study was to investigate the effect of stabilized hypochlorous acid (HOCl) on killing rate, biofilm formation, antimicrobial activity within biofilm against frequently isolated microorganisms and migration rate of wounded fibroblasts and keratinocytes.”
Serban Sakarya, MD; Necati Gunay, MS; Meltem Karakulak, MS; Barcin Ozturk, MD; Bulent Ertugrul, MD
“Abstract: Necrotizing fasciitis (NF), commonly known as flesh-eating disease, is an infection of the deeper layers of skin and subcutaneous tissues, easily spreading across the fascial plane within the subcutaneous tissue. NF is a quickly progressing and severe disease of sudden onset and is treated immediately with massive debridement and intravenous antibiotics. Despite aggressive treatment, mortality rate and loss of limbs remain high (10-70%). This is because the disease is frozen in the inflammatory phase II of wound healing. While bacteria are killed by antibiotics, remaining bacterial toxins and superantigens produce massive inflammatory response. Objective: to evaluate a new treatment for NF”
John R. Crew, MD, Randell Varilla, RN, MSN, Thomas Allandale Rocas III, RN, BSN, CWCN, Dmitri Debabov, PhD
“Abstract: Necrotizing Fasciitis is a complication of a bacterial infection that activates the immune system in perifascial planes. This case report hightlights initial diagnostic failures that delay early treatment, which causes profoundly negative consequences. Antimicrobial control with abolition of the inciting bacteria does not neutralize the subsequent endopathologic ravages. A new technique, which combines negative pressure wound therapy (NPWT) and a pure hypochlorous acid solution (NeutroPhase) along with debridement and antiobiotics is described in this study. It is believed that the combination of neutralization of the toxins produced by bacteria with NeutroPhase along with the NPWT action of removing exudates is effective in saving the patient.
John R. Crew, MD1; Randell Varilla, RN, MSN1; Thomas Allandale Rocas III, RN, BSN, CWCN1; Suriani Abdul Rani, MS2; Dmitri Debabov, PhD2
An ascending infection of the right forefoot with a diabetic ulcer and diabetic neuropathy is treated with NeutroPhase.
Martin J. Winkler MD FACS