Flow Through Instillation of Hypochlorous Acid in the Treatment of Necrotizing Fasciitis 

“Abstract: Necrotizing Fasciitis (NF) is a rare and rapidly progressing bacterial infection of soft tissues. Bacterial toxins cause local tissue damage and necrosis, as well as blunt immune system responses. A self-propagating cycle of bacterial invasion, toxin release and tissue destruction can continue until substantial amounts of tissue become necrotic. Neutralization of bacterial toxins should improve the results.”

Dr. John Crew, MD, Kerry Thibodeaux, MD, FACS, Marcus Speyrer, RN, CWS, Anibal R. Gauto, MD, Timothy Shiau, PhD, Liliana Pang, Keith Bley, PhD, and Dmitri Debabov, PhD

Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency 

“Abstract: Chronic wounds and the infections associated with them are responsible for a considerable escalation in morbidity and the cost of health care. Infection and cellular activation and the relation between cells are 2 critical factors in wound healing. Since chronic wounds offer ideal conditions for infection and biofilm production, good wound care strategies are critical for wound healing. Objective: The aim of this study was to investigate the effect of stabilized hypochlorous acid (HOCl) on killing rate, biofilm formation, antimicrobial activity within biofilm against frequently isolated microorganisms and migration rate of wounded fibroblasts and keratinocytes.”

Serban Sakarya, MD; Necati Gunay, MS; Meltem Karakulak, MS; Barcin Ozturk, MD; Bulent Ertugrul, MD

Minimally Invasive Surgery for Necrotizing Fasciitis

“Abstract: Necrotizing fasciitis (NF), commonly known as flesh-eating disease, is an infection of the deeper layers of skin and subcutaneous tissues, easily spreading across the fascial plane within the subcutaneous tissue. NF is a quickly progressing and severe disease of sudden onset and is treated immediately with massive debridement and intravenous antibiotics. Despite aggressive treatment, mortality rate and loss of limbs remain high (10-70%). This is because the disease is frozen in the inflammatory phase II of wound healing. While bacteria are killed by antibiotics, remaining bacterial toxins and superantigens produce massive inflammatory response. Objective: to evaluate a new treatment for NF”

John R. Crew, MD, Randell Varilla, RN, MSN, Thomas Allandale Rocas III, RN, BSN, CWCN, Dmitri Debabov, PhD

The In Vitro Antimicrobial Activity of Wound and Skin Cleansers at Nontoxic Concentrations

Antimicrobial Activity Comparison of Pure Hypochlorous Acid (0.01%) with Other Wound and Skin Cleansers at Non-Toxic Concentrations

Russell Hoon, Suriani Abdul Rani, RaminNajafi, Lu Wang, Dmitri Debabov NovaBayPharmaceuticals, Inc. 5980 Horton Street, Suite 550, Emeryville, CA 94608

Limb Threatening Acute Right Small Toe Diabetic Ulcer with Infected Bone and Ascending Infection

Martin J. Winkler MD FACS

Treatment of Acute Necrotizing Fasciitis Using Negative Pressure Wound Therapy and Adjunctive NeutroPhase Irrigation Under the Foam

John R. Crew, MD1; Randell Varilla, RN, MSN1; Thomas Allandale Rocas III, RN, BSN, CWCN1; Suriani Abdul Rani, MS2; Dmitri Debabov, PhD2